| Reader, A breakthrough study published in the Journals of Gerontology found that a simple supplement combination increased lifespan and reversed age-related decline brought on by oxidative stress.1
As a regular reader, you know that oxidative stress causes all the classic hallmarks most people have come to associate with aging – both inside your body and out.
The good news is that you can reverse this damage.
In the study, not only did the participants ward off several key indicators of aging, but they were also fitter… stronger… slimmer… and had better metabolic health.
Of course, you'll never hear about this from Big Pharma. And you won't see it in ads by Big Beauty.
After all, these behemoths make their fortunes selling you their prescription pills and anti-aging potions.
But let's be clear…
The frailty that happens as your muscle mass vanishes… The belly fat that won't budge… The sexual vigor that's no longer as potent as it once was… The wrinkles on your face appear to get deeper each time you look in the mirror…
They are all the result of oxidative stress.
And inside your body, the damage is even more extreme. Oxidative stress leads to cell destruction that causes: - Inflammation
- Insulin resistance and diabetes
- Endothelial dysfunction, which leads to high blood pressure, heart disease, and a compromised immune system
- Dysfunction in your mitochondria – the power generators that provide the energy your cells need to function
- DNA damage
- Stem cell fatigue leads to your body's inability to repair damaged organs and tissues
- Cellular senescence, which causes a buildup of zombie cells and degenerative aging
Patients often ask me where oxidative stress comes from.
Oxidation occurs as a natural byproduct of our cellular energy production. And it's the price that all air-breathing animals pay for burning oxygen to make energy.
Our bodies naturally rebalance when we consume antioxidants, like berries or vegetables like broccoli and beets.
The lasting damage occurs when you add in additional factors that our bodies weren't made to withstand over time.
I'm talking about the typical nutrition-less American diet, a lack of exercise, air pollution, and the constantly high cortisol levels that come from living in our frenzied 24/7 world.
You can't escape this added oxidative stress.
But you can do something about it.
The Journals of Gerontology study revealed that supplementing with a combination of two amino acids—glycine and N-acetylcysteine—can reverse the biological hands of time that have been accelerated by oxidative stress.
In a randomized, double-blind clinical trial of seniors aged between 61 and 85, researchers found that participants who took GlyNAC experienced remarkably less oxidative stress in their bodies...
And that mitochondrial function had improved in their muscles, along with better heart, liver, and kidney function – after just 16 weeks.2
One of the main reasons GlyNAC has such powerful anti-aging properties is that both glycine and N-acetylcysteine are essential for the production of glutathione. This is your body's most powerful antioxidant to clear away oxidative damage.
The problem is that glutathione declines when you age. But when you boost its production in your body, it naturally reverses your biological clock.3
At the same time, glycine is critical for keeping your brain and central nervous system free of oxidative damage that can trigger neurodegenerative diseases like Parkinson's and Alzheimer's.
It's hardly surprising this important study was ignored by the media – given the influence of Big Pharma's expensive and potentially dangerous drugs that claim to disrupt the aging process. Start To Reverse Aging In Less Than An Hour At the Sears Institute for Anti-Aging Medicine, I've been helping my patients get more glycine and N-acetylcysteine – and increase glutathione – through IV therapy.
It's the fastest and most effective way to boost levels.
But there are easy ways to increase levels at home. Here's what I suggest:  Grass-fed beef, pastured chicken and eggs, and wild-caught fish are a great way to get more glycine and NAC naturally. | - Get more through your diet. It's easy to increase levels of glycine and NAC by making smart food choices. Your best choices include high-protein foods like grass-fed beef, pastured chicken and eggs, and wild-caught fish.
Also increase the amount of full-fat hard cheese and yogurt, cauliflower, cabbage, red peppers, and Brussels sprouts you eat.
- Supplement with NAC. N-acetylcysteine (NAC) is a supplement form of the amino acid cysteine. I recommend taking 600 mg by tablet or capsule per day. After a couple of weeks, take 600 mg twice a day.
In one study, patients who supplemented with NAC twice daily day for one month experienced increased glutathione blood levels and reduced oxidative stress.4
- Then add in glycine. Glycine is considered a non-essential amino acid. But don't tell that to your body! This powerful nutrient is essential for anti-aging.
Studies show it decreases both oxidative stress and inflammation in humans.5 In animal studies, it extended lifespan by up to 40%.6
I recommend taking at least 1,000 mg of this supplement daily.
To Your Good Health, 
Al Sears, MD, CNS
References: - Kumar P, et al. "Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: A randomized clinical trial." J Gerontol. 2023;78(1):75–89.
- Kumar P, et al. "Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: A randomized clinical trial." J Gerontol. 2023;78(1):75–89.
- Montserrat M, et al. "Mitochondrial glutathione, a key survival antioxidant." Antioxid Redox Signal. 2009; 11(11): 2685–2700.
- Paschalis V, et al. "N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione." Free Radic Biol Med. 2018 Feb 1:115:288-297.
- Canfield C, and Bradshaw P. "Amino acids in the regulation of aging and aging-related diseases." Transl Med Aging. 2019;3(1).
- Brind J, et al. "Dietary glycine supplementation mimics lifespan extension by dietary methionine restriction in Fisher 344 rats." FASEB J. 2011;25.
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